Developing thymocytes roll the Dice(r)

Rescuing developing thymocytes from death by neglect.

The major function of the thymus is to eliminate developing thymocytes that are potentially useless or autoreactive, and select only those that bear functional T cell antigen receptors (TCRs) through fastidious screening. It is believed that glucocorticoids (GCs) are at least in part responsible for cell death during death by neglect. In this review, we will mainly cover the topic of the GC-ind...

Double-Strand Breaks Proliferating Thymocytes Experiencing DNA Requirement for Dicer in Survival of

In Vivo Detection of Intracellular Signaling Pathways in Developing Thymocytes

Information regarding the intracellular signaling processes that occur during the development of T cells has largely been obtained with the use of transgenic mouse models, which although providing invaluable information are time consuming and costly. To this end, we have developed a novel system that facilitates the in vivo analysis of signal transduction pathways during T-lymphocyte developmen...

Two waves of recombinase gene expression in developing thymocytes

During T cell development in the thymus, T cell receptor (TCR) alpha, beta, gamma, and delta genes are rearranged and expressed. TCR rearrangement strictly depends upon the coordinate activity of two recombinase activating genes, Rag-1 and Rag-2. In this study we have followed the expression of these genes at different stages of intrathymic development. The results indicate that there are two p...

Expression in Developing Thymocytes Ikaros Regulates Notch Target Gene